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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

para-AMINOAZOBENZENE
(Group 2B)

For definition of Groups, see Preamble Evaluation.

Supplement 7: (1987) (p. 390)

CAS No.: 60-09-3
Chem. Abstr. Name: 4-(Phenylazo)benzenamine

Evidence for carcinogenicity to animals (sufficient)

para-Aminoazobenzene produced liver tumours in rats following its oral administration and produced epidermal tumours in rats after application to the skin [ref: 1]. In mice, hepatomas were found in 50-100% of males after one or four intraperitoneal injections of para-aminoazobenzene, compared to 3% in controls and in females. In two other strains of mice, 93% and 46% of males had hepatomas at 11 months of age after a single intraperitoneal injection of the compound [ref: 2]. When pregnant and newborn male and female mice were administered high doses of para-aminoazobenzene by subcutaneous injection, there was a borderline increase in the incidences of tumours of the liver and of the haematopoietic and lymphoid tissues in mice treated transplacentally and a statistically significant increase in the incidence of these tumours in neonates [ref: 3].

Overall evaluation

para-Aminoazobenzene is possibly carcinogenic to humans (Group 2B).

For definition of the italicized terms, see Preamble Evaluation.

Also see previous evaluation: Vol. 8 (1975)

References

1. IARC Monographs, 8, 53-60, 1975

2. Delclos, K.B., Tarpley, W.G., Miller, E.C. & Miller, J.A. (1984) 4-Aminoazobenzene and N,N-dimethyl-4-aminoazobenzene as equipotent hepatic carcinogens in male C57BL/6xC3H/HeF1 mice and characterization of N-(deoxyguanosin-8-yl)-4-aminoazobenzene as the major persistent hepatic DNA-bound dye in these mice. Cancer Res., 44, 2540-2550

3. Fujii, K. (1983) Induction of tumors in transplacental or neonatal mice administered 3'-methyl-4-dimethylaminoazobenzene or 4-aminoazobenzene. Cancer Lett., 17, 321-325

Synonyms

  • AAB
  • Aminoazobenzene
  • 4-Aminoazobenzene
  • 4-Amino-1,1'-azobenzene
  • Aminoazobenzene [indicator]
  • 4-Aminoazobenzol
  • para-Aminoazobenzol
  • para-Aminoazotoluene
  • para-Aminodiphenylimide
  • Aniline Yellow
  • 4-Benzeneazoaniline
  • Brasilazina oil Yellow G
  • Ceres Yellow R
  • Fast spirit Yellow
  • Fast spirit Yellow AAB
  • Fat Yellow AAB
  • Induline R
  • Oil-sol. aniline Yellow
  • Oil Yellow AAB
  • Oil Yellow AN
  • Oil Yellow B
  • Oil Yellow 2G
  • Oil Yellow R
  • Organol Yellow
  • Organol Yellow 2A
  • Paraphenolazo aniline
  • para-(Phenylazo)aniline
  • 4-(Phenylazo)benzenamine
  • para-Phenylazophenylamine
  • Solvent Yellow 1
  • Somalia Yellow 2G
  • Stearix brown 4R
  • Sudan Yellow R
  • Sudan Yellow RA


    Last updated: 27 February 1998
    
    
    
    
    
    
    
    
    
    
    
    
    
    
    
    
    
    
    
    
    
    
    
    
        See Also:
           Toxicological Abbreviations