For definition of Groups, see Preamble Evaluation.
Supplement 7: (1987) (p. 312)
Chem. Abstr. Name: Hydrazine(2-phenylethyl)-, sulfate(1:1)
A. Evidence for carcinogenicity to humans (inadequate)
A liver angiosarcoma was reported in one person who had taken phenelzine sulphate for six years preceding tumour diagnosis [ref: 1].
B. Evidence for carcinogenicity to animals (limited)
Phenelzine sulphate was administered to mice in drinking-water for life. Incidences of lung and blood-vessel tumours were significantly increased in female but not in male mice [ref: 1].
C. Other relevant data
No data were available on the genetic and related effects of phenelzine sulphate in humans. It did not induce DNA strand breaks in mice treated in vivo. In bacteria, it was mutagenic and induced DNA damage [ref: 2].
Phenelzine sulphate is not classifiable as to its carcinogenicity to humans (Group 3).
For definition of the italicized terms, see Preamble Evaluation.
Also see previous evaluation: Vol. 24 (1980)
1. IARC Monographs, 24, 175-184, 1980
2. IARC Monographs, Suppl. 6, 453-454, 1987
See Also: Toxicological Abbreviations