For definition of Groups, see Preamble Evaluation.
Supplement 7: (1987) (p. 392)
Chem. Abstr. Name: (1,1'-Biphenyl)-2-ol, sodium salt
B. Evidence for carcinogenicity to animals (sufficient)
Sodium ortho-phenylphenate produced urinary bladder carcinomas in rats following its oral administration [ref: 1-3]. It increased the incidences of haemangiosarcomas of the liver and of hepatocellular carcinomas in male mice after its oral administration [ref: 4]. When given in the diet to rats, it enhanced the incidence of bladder cancer induced by oral administration of N-nitroso-N-(4-hydroxybutyl)-N-butylamine [ref: 5].
Sodium ortho-phenylphenate is possibly carcinogenic to humans (Group 2B).
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Vol. 73 (1999)
Also see previous evaluation: Vol. 30 (1983)
1. IARC Monographs, 30, 329-344, 1983
2. Fujii, T. & Hiraga, K. (1985) Carcinogenicity testing of sodium ortho-phenylphenate in F344 rats (Jpn.). J. Saitama med. School,12, 277-287
3. Fujii, T., Mikuriya, H., Kamiya, N. & Hiraga, K. (1986) Enhancing effect of thiabendazole on urinary bladder carcinogenesis induced by sodium o-phenylphenate in F344 rats. Foodchem. Toxicol., 24, 207-211
4. Hagiwara, A., Shibata, M., Hirose, M., Fukushima, S. & Ito, N. (1984) Long-term toxicity and carcinogenicity study of sodium o-phenylphenate in B6C3F1 mice. Food chem. Toxicol., 22, 809-814
5. Fukushima, S., Kurata, Y., Shibata, M., Ikawa, E. & Ito, N. (1983) Promoting effect of sodium o-phenylphenate and o-phenylphenol on two-stage urinary bladder carcinogenesis in rats. Gann, 74, 625-632
See Also: Toxicological Abbreviations