International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 1 (1972) (p. 135)
5. Summary of Data Reported and Evaluation
5.1 Animal carcinogenicity data
Nitrosoethylurea is carcinogenic in all four animal species tested.
The main target organs are the kidney, nervous system and
lympho-reticular system. Tumours have been induced following
different routes of administration, including single oral doses.
Prenatal exposure to the substance has been shown to be particularly
effective in producing tumours of the nervous system.
5.2 Human carcinogenicity data
The compound can be formed from ethylurea by nitrosation in vivo. No
data on direct human exposure are available.
Subsequent evaluations: Vol. 17 (1978); Suppl. 7 (1987) (p. 63: Group 2A)
For definition of Groups, see Preamble Evaluation.
Last updated: 12 March 1998