International Agency for Research on Cancer (IARC) - Summaries & Evaluations
SAFROLE, ISOSAFROLE AND DIHYDROSAFROLE
VOL.: 1 (1972) (p. 169)
5. Summary of Data Reported and Evaluation
5.1 Animal carcinogenicity data
Safrole and isosafrole are liver carcinogens for the mouse and the rat
when administered orally or subcutaneously. Dihydrosafrole is
carcinogenic for the oesophagus of the rat following oral
administration.
5.2 Human carcinogenicity data
Man may ingest small amounts of safrole and isosafrole through
essential oils in which they occur.
No epidemiological data are available on the effects of human
exposure.
Subsequent evaluation: Vol. 10 (1976);
Suppl. 7 (1987) (p. 62: Dihydrosafrole - Group 2B; p. 65: Isosafrole - Group 3; p. 71: Safrole - Group 2B)
For definition of Groups, see Preamble Evaluation.
Last updated: 16 March 1998