International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 3 (1973) (p. 260)
5. Summary of Data Reported and Evaluation
5.1 Animal carcinogenicity data
7H-Dibenzo(c,g)carbazole is carcinogenic in the mouse, rat, hamster and possibly in
the dog. It has both a local and systemic carcinogenic effect.
Following oral administration in the mouse, forestomach tumours and
hepatomas occurred; intratracheal administration to hamsters produced
tumours of the respiratory tract. In comparison with benzo(a)pyrene,
7H-dibenzo(c,g)carbazole appears to be a stronger respiratory tract carcinogen for
5.2 Human carcinogenicity data
No case reports or epidemiological studies on the significance of
7H-dibenzo(c,g)carbazole exposure to man are available. The substance has been
detected in cigarette tar. The possible contribution of heterocyclic
compounds from some environmental sources to the overall carcinogenic
risk to man is discussed in the General Remarks.
Subsequent evaluations: Vol. 32 (1983); Suppl. 7 (1987) (p. 61: Group 2B)
For definition of Groups, see Preamble Evaluation.
Last updated: 16 March 1998