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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

7H-DIBENZO(c,g)CARBAZOLE

VOL.: 3 (1973) (p. 260)

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

7H-Dibenzo(c,g)carbazole is carcinogenic in the mouse, rat, hamster and possibly in the dog. It has both a local and systemic carcinogenic effect. Following oral administration in the mouse, forestomach tumours and hepatomas occurred; intratracheal administration to hamsters produced tumours of the respiratory tract. In comparison with benzo(a)pyrene, 7H-dibenzo(c,g)carbazole appears to be a stronger respiratory tract carcinogen for the hamster.

5.2 Human carcinogenicity data

No case reports or epidemiological studies on the significance of 7H-dibenzo(c,g)carbazole exposure to man are available. The substance has been detected in cigarette tar. The possible contribution of heterocyclic compounds from some environmental sources to the overall carcinogenic risk to man is discussed in the General Remarks.

Subsequent evaluations: Vol. 32 (1983); Suppl. 7 (1987) (p. 61: Group 2B)

For definition of Groups, see Preamble Evaluation.


Last updated: 16 March 1998






















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