VOL.: 3 (1973) (p. 178)
On oral administration, it produced tumours of the forestomach in the mouse; intratracheal administration to rats produced lung tumours.
In repeated skin painting experiments in mice, dibenz(a,h)anthracene and benzo(a)pyrene appeared to be equally effective. In a dose-response study on s.c. carcinogenicity with dibenz(a,h)anthracene, benzo(a)pyrene and 3-methylcholanthrene, dibenz(a,h)anthracene was shown to be effective at a lower dose than that effective for benzo(a)pyrene or for 3-methylcholanthrene; its latent period, however, was longer. Dibenz(a,h)anthracene induced local sarcomas and increased the incidence of lung adenomas following a single s.c. injection in newborn mice at dose levels which were ineffective with 3-methylcholanthrene.
It has not been adequately tested in other species.
Subsequent evaluation: Vol. 32 (1983); Suppl. 7 (1987) (p. 61: Group 2A)
For definition of Groups, see Preamble Evaluation.
See Also: Toxicological Abbreviations