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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

DIBENZO(a,i)PYRENE

VOL.: 3 (1973) (p. 215)

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

Subcutaneous injections of dibenzo(a,i)pyrene resulted in the rapid appearance of local sarcomas in the hamster and the mouse. The smallest single dose which produced sarcomas in mice was 50 mg. Repeated skin application in mice was also effective, but dibenzo(a,i)pyrene was less active than benzo(a)pyrene. It has not been tested by other routes or in other species.

5.2 Human carcinogenicity data

No case reports or epidemiological studies on the significance of dibenzo(a,i)pyrene exposure to man are available. However, coal-tar and other materials which are known to be carcinogenic to man may contain dibenzo(a,i)pyrene. The substance has also been detected in other environmental situations. The possible contribution of polycyclic aromatic hydrocarbons from some environmental sources to the overall carcinogenic risk to man is discussed in the General Remarks.

Subsequent evaluations: Vol. 32 (1983); Suppl. 7 (1987) (p. 62: Group 2B)

For definition of Groups, see Preamble Evaluation.


Last updated: 16 March 1998






















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