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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

INDENO(1,2,3-cd)PYRENE

VOL.: 3 (1973) (p. 229)

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

Indeno(1,2,3-cd)pyrene is a complete carcinogen and an initiator for skin carcinogenesis in the mouse. It produces local sarcomas in the same species after subcutaneous injection. It seems to be of lower potency as a skin carcinogen than benzo(a)pyrene. It has not been tested by other routes in the mouse or in other species.

5.2 Human carcinogenicity data

No case reports or epidemiological studies on the significance of indeno(1,2,3-cd)pyrene exposure to man are available. However, coal-tar and other materials which are known to be carcinogenic to man may contain indeno(1,2,3-cd)pyrene. The substance has also been detected in other environmental situations. The possible contribution of polycyclic aromatic hydrocarbons from some environmental sources to the overall carcinogenic risk to man is discussed in the General Remarks.

Subsequent evaluations: Vol. 32 (1983); Suppl. 7 (1987) (p. 64: Group 2B)

For definition of Groups, see Preamble Evaluation.


Last updated: 16 March 1998






















    See Also:
       Toxicological Abbreviations
       Indeno(1,2,3-cd)pyrene (ICSC)