International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 4 (1974) (p. 97)
5. Summary of Data Reported and Evaluation
5.1 Animal carcinogenicity data
2-Naphthylamine is carcinogenic in the mouse, hamster, dog and monkey.
Given orally it has produced bladder carcinomas in the dog and monkey,
and, at high dosage levels, in the hamster. By this route, it has
increased the incidence of hepatomas in the mouse; in the rat and
rabbit, it has little, if any, carcinogenic effect.
5.2 Human carcinogenicity data
Epidemiological studies have shown that occupational exposure to
2-naphthylamine, either alone or when present as an impurity in other
compounds, is strongly associated with the occurrence of bladder
cancer. There is no doubt that 2-naphthylamine is a human bladder
Subsequent evaluation: Suppl. 7 (1987)
Last updated: 16 March 1998