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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

N,N-BIS(2-CHLOROETHYL)-2-NAPHTHYLAMINE
(CHLORNAPHAZINE)

VOL.: 4 (1974) (p. 119)

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

N,N-Bis(2-chloroethyl)-2-naphthylamine is carcinogenic to the mouse lung by the intraperitoneal route and has a local carcinogenic effect in rats following subcutaneous injection.

5.2 Human carcinogenicity data

This drug has been administered to man with 32P sodium phosphate for the treatment of polycythaemia and of neoplasias of the haemopoietic system in doses of up to 400 mg/day. Follow-up studies have shown that under these conditions, the drug is carcinogenic, producing bladder tumours after administration of total doses as low as 4 g.

Subsequent evaluation: Suppl. 7 (1987)


Last updated: 16 March 1998






















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