International Agency for Research on Cancer (IARC) - Summaries & Evaluations
ISONICOTINIC ACID HYDRAZIDE (ISONIAZID)
VOL.: 4 (1974) (p. 159)
5. Summary of Data Reported and Evaluation
5.1 Animal carcinogenicity data
Isonicotinic acid hydrazide (INH) is carcinogenic in mice after oral,
subcutaneous and intraperitoneal administration. The observation of
tumours in rats in only one of several oral studies is inconclusive.
INH failed to produce tumours in hamsters when given orally.
5.2 Human carcinogenicity data
Available evidence from the first 15 years of human exposure has not
suggested that INH is carcinogenic in man in the doses applicable to
treatment and prophylaxis of tuberculosis.
Subsequent evaluation: Suppl. 7 (1987)
Last updated: 16 March 1998