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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

BHC (TECHNICAL GRADES) AND LINDANE

VOL.: 5 (1974) (p. 47)

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

Technical BHC, its pure a-, b- and g-isomers and the mixture of d + e isomers are carcinogenic in mice, producing liver-cell tumours following oral administration. This effect was recorded in both sexes after exposure to the b- and g-isomers; the technical compound, the a-isomer and the d + e mixture were tested in male mice only.

Available feeding studies in rats were considered inadequate either because survival rates were low, the information reported was insufficient or because the doses given were too low.

No tumours were reported in limited skin application and subcutaneous implantation studies in mice.

5.2 Human carcinogenicity data

No epidemiological studies were available to the Working Group. Patients dying with cancer did not show higher concentrations of BHC in fat tissues and liver than did control patients.

No firm conclusions as to a causal relationship with aplastic anaemia and/or leukaemia can be drawn from available case reports.

Subsequent evaluations: Vol. 20 (1979); Suppl. 7 (1987)


Last updated: 17 March 1998






















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