International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 5 (1974) (p. 193)
5. Summary of Data Reported and Evaluation
5.1 Animal carcinogenicity data
Methoxychlor was tested by the oral route only in the rat. Three
experiments, including one employing dietary levels of up to 1600 ppm
(equivalent to about 80 mg/kg bw/day), provided no evidence of
carcinogenicity. Because of inadequate reporting, conclusions cannot
be drawn from the results of a fourth experiment in which some liver
tumours were observed in rats fed up to 2000 ppm in the diet
(equivalent to about 100 mg/kg bw/day). Data from these four
experiments do not allow an evaluation of the carcinogenicity of
methoxychlor to be made at the present time.
No tumours were reported in limited skin application and subcutaneous
injection (single-dose) studies.
5.2 Human carcinogenicity data
No epidemiological studies were available to the Working Group.
Subsequent evaluation: Vol. 20 (1979);
Suppl. 7 (1987) (p. 66: Group 3)
For definition of Groups, see Preamble Evaluation.
Last updated: 17 March 1998