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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

ETHYNODIOL DIACETATE

VOL.: 6 (1974) (p. 173)

5. Comments on Data Reported and Evaluation

(N.B.: This section should be read in conjunction with the section ' General Conclusions on Hormones'.)

5.1 Animal carcinogenicity data

Ethynodiol diacetate was tested alone or in combination with oestrogens by the oral route in mice and rats. Given alone, it did not increase the incidence of tumours in female mice or female rats; in castrated male mice it increased the incidence of mammary tumours, and in male rats it produced benign mammary tumours. In combination with oestrogens it increased the incidence of malignant mammary tumours in some groups of male and female rats.

5.2 Human carcinogenicity data

No case reports or epidemiological studies on ethynodiol diacetate alone were available to the Working Group. Epidemiological studies on steroid hormones used in oestrogen-progestin contraceptive preparations have been summarized in the section, "Oestrogens and Progestins in Relation to Human Cancer", in this volume.

Subsequent evaluations: Vol. 21 (1979); Suppl. 7 (1987) (Progestins; Combined oral contraceptives)


Last updated: 20 March 1998






















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