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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

MEDROXYPROGESTERONE ACETATE

VOL.: 6 (1974) (p. 157)

5. Summary of Data Reported and Evaluation

(N.B.: This section should be read in conjunction with the section 'General Conclusions on Hormones'.)

5.1 Animal carcinogenicity data

Medroxyprogesterone acetate was tested by the intramuscular route in dogs and produced malignant mammary tumours. Full details were not available to the Working Group. The significance of the finding in dogs is discussed in the section, "General Remarks on the Sex Hormones", in this volume.

5.2 Human carcinogenicity data

No case reports or epidemiological studies on medroxyprogesterone acetate alone were available to the Working Group. Epidemiological studies on steroid hormones used in oestrogen-progestin contraceptive preparations have been summarized in the section, "Oestrogens and Progestins in Relation to Human Cancer", in this volume.

Subsequent evaluations: Vol. 21 (1979); Suppl. 7 (1987)


Last updated: 18 March 1998






















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