VOL.: 6 (1974) (p. 135)
When given alone, it increased the incidence of ovarian, uterine or mammary tumours in mice, while the experiment in dogs was of insufficient duration to allow an assessment to be made.
The administration of progesterone to intact or castrated mice and rats and to rabbits in combination with polycyclic aromatic hydrocarbons or with 2-acetylaminofluorene and/or oestrogen variously affected the incidence and the histological type of the tumours produced by these known carcinogens (mainly mammary, uterine and vaginal tumours). In particular, progesterone enhanced the incidence of tumours produced by these known carcinogens, but only when given after and not before their administration.
Subsequent evaluations: Vol. 21 (1979); Suppl. 7 (1987) (Progestins; Combined oral contraceptives)
See Also: Toxicological Abbreviations PROGESTERONE (JECFA Evaluation)