Thiouracil (IARC Summary & Evaluation, Volume 7, 1974)

International Agency for Research on Cancer (IARC) - Summaries & Evaluations

THIOURACIL

VOL.: 7 (1974) (p. 85)

CAS No.: 141-90-2

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

Thiouracil increased the incidence of liver-cell tumours in mice and produced thyroid tumours in several strains of rats following oral administration, the only route tested. Studies in cats, dogs and monkeys were inadequate in group size and duration to allow evaluation of carcinogenicity. The study in fish reported did not demonstrate a significant carcinogenic effect.

5.2 Human carcinogenicity data

No adequate case reports or epidemiological studies were available to the Working Group.

Subsequent evaluations: Suppl. 7 (1987) (p. 72); Vol. 79 (2001) (p. 127)

For definition of Groups, see Preamble Evaluation.

Synonyms for Thiouracil

Antagothyroid
Deracil
2,3-Dihydro-2-thioxo-4(1H)-pyrimidinone
6-Hydroxy-2-mercapto-pyrimidine
2-Mercapto-4-hydroxypyrimidine
2-Mercapto-4-pyrimidinol
2-Mercapto-4-pyrimidone
2-Mercapto-pyrimid-4-one
2-Thio-4-oxo-1,3-pyrimidine
2-Thio-2,4-(1H,3H)-pyrimidinedione
2-Thio-1,3-pyrimidin-4-one
2-Thiouracil
6-Thiouracil
TU
2-TU

Last updated: 20 March 1998





























    See Also:
       Toxicological Abbreviations
       Thiouracil  (IARC Summary & Evaluation, Volume 79, 2001)