International Agency for Research on Cancer (IARC) - Summaries & Evaluations
para-DIMETHYLAMINOAZOBENZENE
VOL.: 8 (1975) (p. 125)
CAS No.: 60-11-7
Chem. Abstr. Name: N, N-Dimethy1-4-(phenylazo)-benzenamine
5. Summary of Data Reported and Evaluation
5.1 Animal carcinogenicity data
para-Dimethylaminoazobenzene (DAB) is carcinogenic in rats, producing
liver tumours after its administration by several routes, and in dogs,
producing bladder tumours following its administration by the oral
route. Results of oral administration studies were doubtful in mice
and negative in hamsters and guinea-pigs; but these studies were of
short duration, and the adequacy of the dose levels used was not
known.
DAB has also been tested by subcutaneous injection in mice, and the
results are suggestive of local and hepatic carcinogenicity. Treatment
of newborn animals produced systemic carcinogenic effects in mice; the
negative results obtained in rats are doubtful, since the period of
observation was too short. Skin-painting with DAB produced
epidermal tumours in rats but not in mice.
An extensive dose-response study was carried out in rats: the lowest
effective dose was 1 mg/rat/day and the highest non-effective dose,
0.3 mg/rat/day.
5.2 Human carcinogenicity data
No case reports or epidemiological studies were available to the
Working Group.
Subsequent evaluation: Suppl. 7 (1987) (p. 62: Group 2B)
For definition of Groups, see Preamble Evaluation.
Synonyms
- Atul fast Yellow R
- Brilliant Fast Oil Yellow
- Brilliant Fast Spirit Yellow
- Brilliant Fast Yellow
- Brilliant Oil Yellow
- Butter or methyl Yellow
- Cerasine Yellow GG
- C.I. Solvent Yellow 2
- 4-Dimethylaminoethylbenzene
- N
,N-Dimethyl-p-azoaniline
- N
,N-Dimethyl-p-phenylazoaniline
- Dimethyl Yellow
- Dimethyl Yellow N,N-dimethylaniline
- DMAB
- Enial Yellow 2G
- Fast Oil Yellow B
- Fast Yellow
- Grasal Brilliant Yellow
- Methyl Yellow
- Oleal Yellow 2G
- Organol Yellow ADM
- Orient Oil Yellow GG
- Petrol Yellow WT
- Resinol Yellow GR
- Resoform Yellow GGA
- Silotras Yellow T2G
- Somalia Yellow A
- Stéar Yellow JB
- Sudan Yellow GG
- Sudan Yellow GGA
- Toyo oil Yellow G
- Waxoline Yellow AD
- Waxoline Yellow ADS
- Yellow G soluble in grease
Last updated: 21 March 1998