International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 9 (1975) (p. 125)
5. Summary of Data Reported and Evaluation
5.1 Animal carcinogenicity data
Chlorambucil is carcinogenic in mice and rats following its
intraperitoneal injection, producing lymphomas in rats and
lymphosarcomas, ovarian tumours and a dose-related increase in the
incidence of lung tumours in mice.
5.2 Human carcinogenicity data
The available case reports in which leukaemia and other tumours were
reported to have occurred in patients treated with chlorambucil
provide insufficient evidence to determine if there is an increased
incidence of cancer following the therapeutic use of this drug.
Subsequent evaluation: Vol. 26 (1981); Suppl. 7 (1987)
Last updated: 21 March 1998