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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

NITROGEN MUSTARD N-OXIDE (HYDROCHLORIDE)

VOL.: 9 (1975) (p. 209)

CAS No.: 126-85-2
Chem. Abstr. Name: 2-Chloro-N-(2-chloroethyl)-N-methylethanamine-N-oxide

CAS No.: 302-70-5
Chem. Abstr. Name: 2-Chloro-N-(2-chloroethyl)-N-methylethanamine-N-oxide hydrochloride

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

Nitrogen mustard N-oxide hydrochloride is carcinogenic in mice and rats. Following its subcutaneous injection in mice, it produced lung tumours, thymic lymphomas and Harderian gland adenomas; following its intravenous injection in rats it produced mainly lymphoreticular tumours and sarcomas.

5.2 Human carcinogenicity data

No case reports or epidemiological studies were available to the Working Group.

Subsequent evaluation: Suppl. 7 (1987) (p. 67: Group 2B)

For definition of Groups, see Preamble Evaluation.

Synonyms for Nitrogen mustard N-oxide

Synonyms for Nitrogen mustard N-oxide (hydrochloride)


Last updated: 21 March 1998






















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