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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

DAUNOMYCIN

VOL.: 10 (1976) (p. 145)

CAS No.: 20830-81-3
Chem. Abstr. Name: (8S-cis)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy- a-L-lyxohexa-
pyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-l-methoxy-5,12-naphthacenedione

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

Daunomycin is carcinogenic in rats following intravenous injection of single doses and in mice following its repeated subcutaneous injection; it produced mammary and kidney tumours in rats and local sarcomas in mice. No carcinogenic effect was observed in one oral study in mice.

5.2 Human carcinogenicity data

No case reports or epidemiological studies were available to the Working Group.

Subsequent evaluation: Suppl. 7 (1987) (p. 61: Group 2B)

For definition of Groups, see Preamble Evaluation.

Synonyms


Last updated: 22 March 1998






















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