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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

SAFROLE, ISOSAFROLE, AND DIHYDROSAFROLE

VOL.: 10 (1976) (p. 231)

Safrole
CAS No.: 94-59-7
Chem. Abstr. Name: 5-(2-Propenyl)-1,3-benzodioxole

Isosafrole
CAS No.: 120-58-1
Chem. Abstr. Name: 5- (1-Propenyl) -1,3-benzodioxole

Dihydrosafrole
CAS No.: 94-58-6
Chem. Abstr. Name: 5-Propyl-1,3-benzodioxole

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

Safrole and isosafrole are carcinogenic in mice and rats; they produce liver tumours following their oral administration. Safrole also produced liver and lung tumours in male infant mice following its subcutaneous injection. Dihydrosafrole given orally is carcinogenic in rats, in which it produces tumours of the oesophagus, and in mice, in which it produces liver tumours in males and an increased incidence of lung tumours in both males and females.

5.2 Human carcinogenicity data

No case reports or epidemiological studies were available to the Working Group.

Previous evaluation: Vol. 1 (1972)

Subsequent evaluation: Suppl. 7 (1987) (p. 62: Dihydrosafrole - Group 2B; p. 65: Isosafrole - Group 3; p. 71: Safrole - Group 2B)

For definition of Groups, see Preamble Evaluation.

Synonyms for Safrole

Synonyms for Isosafrole

Synonyms for Dihydrosafrole


Last updated: 22 March 1998






















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       Toxicological Abbreviations