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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

PROPHAM

VOL.: 12 (1976) (p. 189)

CAS No.: 122-42-9
Chem. Abstr. Name: Phenylcarbamic acid, 1-methylethyl ester

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

In one study in which propham was administered orally to two strains of mice, no evidence of carcinogenicity was observed. Other studies in mice, rats and hamsters by oral administration, in mice and rats by subcutaneous injection and in mice by intraperitoneal or intrapleural injection also showed no carcinogenicity, but they were inadequate either in terms of the number of surviving animals, the total dose or the extent of pathology carried out. Orally administered propham acted as an initiator in two-stage carcinogenesis studies in mice.

5.2 Human carcinogenicity data

No case reports or epidemiological studies were available to the Working Group.

Subsequent evaluation: Suppl. 7 (1987) (p. 70: Group 3)

For definition of Groups, see Preamble Evaluation.

Synonyms


Last updated: 25 March 1998






















    See Also:
       Toxicological Abbreviations
       Propham (FAO Meeting Report PL/1965/10/1)
       Propham (Pesticide residues in food: 1992 evaluations Part II Toxicology)