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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

OXYMETHOLONE

VOL.: 13 (1977) (p. 131)

5. Summary of Data Reported and Evaluation

5.1 Animal data

No data were available to the Working Group.

5.2 Human data

Although ten cases of liver-cell tumours have been reported in patients with aplastic anaemia, Fanconi's anaemia or paroxysmal nocturnal haemoglobinuria treated for long periods with oxymetholone alone or in combination with other androgenic drugs, a causal relationship cannot be established.

The increased risk of developing liver-cell tumours could be related to hepatic damage known to be caused by oxymetholone. On the other hand, patients with congenital anaemias many have an intrinsically higher risk of developing tumours; this risk many become manifest during the extended survival resulting from administration of the drug.

Subsequent evaluation: Suppl. 7 (1987) (Androgenic (Anabolic) Steroids)


Last updated: 25 March 1998






















    See Also:
       Toxicological Abbreviations
       Oxymetholone (PIM 915)