International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 13 (1977) (p. 141)
5. Summary of Data Reported and Evaluation
5.1 Animal data
In one limited study in which phenacetin was administered orally to
rats, no carcinogenic effects were observed. One putative metabolite
of phenacetin, N-hydroxyphenacetin, is carcinogenic in rats after its
oral administration: it produced hepatocellular carcinomas.
N.B. - The Working Group was aware that several studies on the
carcinogenicity of phenacetin are underway (IARC, 1976).
5.2 Human data
Available data indicate that heavy use of analgesic mixtures
containing phenacetin is associated with papillary necrosis of the
kidney and suggest a relationship between such use and the development
of transitional-cell carcinoma of the renal pelvis.
Subsequent evaluations: Vol. 24 (1980);
Suppl. 7 (1987)
Last updated: 25 March 1998