International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 15 (1977) (p. 211)

CAS No.: 680-31-9
Chem. Abstr. Name: Hexamethylphosphoric triamide

5. Summary of Data Reported and Evaluation

5.1 Animal data

Hexamethylphosphoramide is carcinogenic in rats, the only species tested, following its administration by inhalation; in this study, which was reported as a preliminary note, it produced squamous-cell carcinomas of the nasal cavity. It has also been inadequately tested in rats by oral administration.

5.2 Human data

No case reports or epidemiological studies were available to the Working Group.

Subsequent evaluation: Vol. 71 (1999)

For definition of Groups, see Preamble Evaluation.


Last updated: 13 April 1999

    See Also:
       Toxicological Abbreviations
       Hexamethylphosphoramide  (IARC Summary & Evaluation, Volume 71, 1999)