International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 16 (1978) (p. 301)

5. Summary of Data Reported and Evaluation1

5.1 Animal data

4,4'-Diaminodiphenyl ether has been tested in rats and mice by oral and subcutaneous administration, producing tumours at various sites. The results suggest carcinogenic activity, but in the absence of contemporary controls, an evaluation of the carcinogenicity of this could not be made.

1 Subsequent to the finalization of this evaluation by the Working Group in June 1977, the Secretariat became aware of a paper by Steinhoff (1977), in which a group of 20 male and 20 female Wistar rats received weekly s.c. injections of 100-300 mg/kg bw 4,4'-diaminodiphenyl ether in saline, up to a total dose of 14.4 g/kg bw, during 670 days. A group of 50 control rats received s.c. injections of saline alone for 907 days. Twenty-two (55%) treated rats died with malignant tumours, compared with 13 (26%) in controls. Benign tumours occurred in 22 treated rats and in 10 controls. Ten (25%) treated rats had malignant tumours of the liver (3 multiple), and 12 had benign liver tumours; no such tumours were found in controls.

5.2 Human data

No case reports or epidemiological studies were available to the Working Group.

Subsequent evaluations: Vol 29 (1982); Suppl. 7 (1987) (p. 61: Group 2B)

For definition of Groups, see Preamble Evaluation.

Last updated: 26 March 1998

    See Also:
       Toxicological Abbreviations