International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 17 (1978) (p. 177)
CAS No.: 621-64-7
Chem. Abstr. Name: N-nitroso-N-propyl-1-propanamine
5. Summary of Data Reported and Evaluation
5.1 Experimental data
N-Nitrosodi-n-propylamine is carcinogenic in rats after its oral
administration and in rats and hamsters after its subcutaneous
injection. It produces benign and malignant tumours of the liver,
kidney, oesophagus and respiratory tract. The metabolite
N-nitroso-N-(2-hydroxy-n-propyl)-n-propylamine is also carcinogenic in rats and
hamsters: it produces benign and malignant tumours of the respiratory
tract and liver after its subcutaneous injection.
5.2 Human data
No case reports or epidemiological studies were available to the
Working Group. Available information on occurrence suggests that
the general population may be exposed sporadically to low levels
of N-nitrosodi-n-propylamine; however, no exposed group suitable for
an epidemiological investigation has yet been identified. The report
of relatively high levels in one pesticide formulation may permit the
identification of exposed groups.
There is sufficient evidence of a carcinogenic effect of
N-nitrosodi-n-propylamine in two experimental animal species. Although
no epidemiological data were available (and efforts should be directed
toward this end), N-nitrosodi-n-propylamine should be regarded for
practical purposes as if it were carcinogenic to humans.
Subsequent evaluation: Suppl. 7 (1987) (p. 68: Group 2B)
For definition of terms, see Preamble Evaluation.
Last updated: 27 March 1998