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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

N-NITROSOPROLINE and N-NITROSOHYDROXYPROLINE

VOL.: 17 (1978) (p. 303)

N-Nitrosoproline
CAS No.: 7519-36-0
Chem. Abstr. Name: 1-Nitroso-L-proline

N-Nitrosohydroxyproline
CAS No.: 30310-80-6
Chem. Abstr. Name: trans-4-Hydroxy-1-nitroso-L-proline

5. Summary of Data Reported and Evaluation

5.1 Experimental data

N-Nitrosoproline has been tested in mice and rats and N-nitrosohydroxyproline in rats by oral administration. Although these studies did not indicate a carcinogenic effect, they were inadequate with regard to dose and/or duration.

5.2 Human data

No case reports or epidemiological studies were available to the Working Group. Available information on occurrence suggests that the general population may be exposed to low levels of N-nitrosoproline and N-nitrosohydroxyproline; however, no exposed group suitable for an epidemiological investigation has yet been identified.

5.3 Evaluation

No evaluation of the carcinogenicity of N-nitrosoproline or N-nitrosohydroxyproline could be made on the basis of the available data.

Subsequent evaluation: Suppl. 7 (1987) (p. 68: Group 3)

For definition of terms, see Preamble Evaluation.

Synonyms


Last updated: 27 March 1998






















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