International Agency for Research on Cancer (IARC) - Summaries & Evaluations
N-NITROSOPROLINE and N-NITROSOHYDROXYPROLINE
VOL.: 17 (1978) (p. 303)
CAS No.: 7519-36-0
Chem. Abstr. Name: 1-Nitroso-L-proline
CAS No.: 30310-80-6
Chem. Abstr. Name: trans-4-Hydroxy-1-nitroso-L-proline
5. Summary of Data Reported and Evaluation
5.1 Experimental data
N-Nitrosoproline has been tested in mice and rats and
N-nitrosohydroxyproline in rats by oral administration. Although these
studies did not indicate a carcinogenic effect, they were inadequate
with regard to dose and/or duration.
5.2 Human data
No case reports or epidemiological studies were available to the
Working Group. Available information on occurrence suggests that the
general population may be exposed to low levels of N-nitrosoproline
and N-nitrosohydroxyproline; however, no exposed group suitable for an
epidemiological investigation has yet been identified.
No evaluation of the carcinogenicity of N-nitrosoproline or
N-nitrosohydroxyproline could be made on the basis of the available
Subsequent evaluation: Suppl. 7 (1987) (p. 68: Group 3)
For definition of terms, see Preamble Evaluation.
Last updated: 27 March 1998