International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 17 (1978) (p. 313)
CAS No.: 930-55-2
Chem. Abstr. Name: 1-Nitrosopyrrolidine
5. Summary of Data Reported and Evaluation
5.1 Experimental data
N-Nitrosopyrrolidine is carcinogenic in rats after its oral
administration: it produces hepatocellular carcinomas. It also
increases the incidence of lung adenomas in mice following its oral
administration. A study in rats has been reported in which a
dose-response relationship was established.
5.2 Human data
No case reports or epidemiological studies were available to the
Working Group. Available information on occurrence suggests that the
general population may be exposed to low levels of
N-nitrosopyrrolidine; however, no exposed group suitable for an
epidemiological investigation has yet been identified.
There is sufficient evidence of a carcinogenic effect of
N-nitrosopyrrolidine in one experimental animal species. Although no
epidemiological data were available, N-nitrosopyrrolidine should be
regarded as if it were carcinogenic to humans.
Subsequent evaluation: Suppl. 7 (1987) (p. 68: Group 2B)
For definition of terms, see Preamble Evaluation.
Last updated: 27 March 1998