VOL.: 20 (1979) (p. 241)
Chem. Abstr. Name: 2,2'-Methylenebis(3,4,6-trichlorophenol)
Hexachlorophene is embryotoxic and produces some teratogenic effects. It was not mutagenic in Salmonella typhimurium and was negative in a dominant lethal assay in male mice. Cytogenetic tests with cultured human lymphocytes were also negative.
N.B. - Subsequent to the meeting of the Working Group, the Secretariat became aware of completed studies on the carcinogenicity of hexachlorophene in which no carcinogenic effects were observed in mice or rats following its oral administration or in mice following exposure prenatally or via the mother's milk or following its s.c. injection to newborn mice (Rudali & Assa, 1978).
Malformations have been reported in children born to mothers repeatedly exposed to hexachlorophene.
The extensive production and use, particularly in germicidal soap, of hexachlorophene over the past several decades indicate that widespread human exposure occurs in both the general and the working environment. This is confirmed by its presence in human body fluids. Episodes of intoxication have also been reported.
Subsequent evaluation: Suppl. 7 (1987) (p. 64: Group 3)
For definition of terms, see Preamble Evaluation.
See Also: Toxicological Abbreviations Hexachlorophene (ICSC)