International Agency for Research on Cancer (IARC) - Summaries & Evaluations
TOXAPHENE (POLYCHLORINATED CAMPHENES)
VOL.: 20 (1979) (p. 327)
CAS No.: 8001-35-2
5. Summary of Data Reported and Evaluation
5.1 Experimental data
Toxaphene (polychlorinated camphenes) was tested in one experiment in
mice and in one in rats by oral administration: a dose-related
increase in the incidence of hepatocellular carcinomas was observed in
male and female mice, and an increased incidence of thyroid tumours
was observed in male and female rats.
Toxaphene is mutagenic in Salmonella typhimurium; it did not induce
dominant lethals in mice.
5.2 Human data
No epidemiological studies relating specifically to the
carcinogenicity of toxaphene were available to the Working Group.
Two cases of acute aplastic anaemia associated with dermal exposure to
toxaphene:lindane mixtures have been reported, one terminating in
death due to acute myelomonocytic leukaemia. The only epidemiological
study that related to possible carcinogenic effects of toxaphene in
humans has weaknesses which prevented the Working Group from drawing
any conclusion specific to toxaphene.
An increased frequency of chromosomal aberrations has been
observed in the lymphocytes of workers exposed to toxaphene.
The extensive production and the widespread use of toxaphene, together
with the persistent nature of the compound, indicate that human
exposure occurs. This is confirmed by many reports of its occurrence
in the general environment.
There is sufficient evidence that toxaphene is carcinogenic in mice
and rats. In the absence of adequate data in humans, it is
reasonable, for practical purposes, to regard toxaphene as if it
presented a carcinogenic risk to humans.
Subsequent evaluation: Suppl. 7 (1987) (p. 72: Group 2B);
Vol. 79 (2001) (p. 569)
For definition of terms, see Preamble Evaluation.
- Agricide Maggot Killer
- Camphofene Huileux
- Chlorinated camphene
- Clor Chem T-590
- Compound 3956
- ENT 9,735
- Hercules 3956
- Hercules Toxaphene
- M 5055
- Synthetic 3956
- Toxon 63
- Vertac 90%
Last updated: 31 March 1998