International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 21 (1979) (p. 139)
5. Summary of Data Reported and Evaluation
(N.B. - This section should be read in conjunction with the General Remarks on Sex Hormones and with
the General Conclusions on Sex Hormones.)
5.1 Experimental data
Chlorotrianisene was tested in only one experiment in rats by oral
administration. The data were insufficient to evaluate the
carcinogenicity of this compound.
5.2 Human data
No case reports or epidemiological studies on chlorotrianisene alone
were available to the Working Group. Case reports and epidemiological studies on steroid
hormones used in oestrogen-progestin contraceptive preparations have been summarized
in the section, 'Oestrogens and Progestins in Relation to Human Cancer'.
The available experimental data are insufficient to evaluate the
carcinogenicity of chlorotrianisene in animals. Studies in humans
strongly suggest that the administration of oestrogens is causally
related to an increased incidence of endometrial carcinoma; there is
no evidence that chlorotrianisene is different from other oestrogens
in this respect.
Subsequent evaluation: Suppl. 7 (1987) (Nonsteroidal oestrogens)
Last updated: 6 April 1998