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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

CLOMIPHENE AND CLOMIPHENE CITRATE

VOL.: 21 (1979) (p. 551)

5. Summary of Data Reported and Evaluation

(N.B. - This section should be read in conjunction with the General Remarks on Sex Hormones and with the General Conclusions on Sex Hormones.)

5.1 Experimental data

Clomiphene citrate was inadequately tested in one experiment in newborn rats by subcutaneous injection; uterine and ovarian tumours were reported.

Clomiphene citrate is embryolethal for pre- and postimplantation embryos in several species and has various teratogenic effects in rats.

5.2 Human data

There are a few case reports of the occurrence of malignant and benign tumours at various sites in patients treated with clomiphene citrate, but there is no evidence of a causal relationship.

No definite association between clomiphene citrate administration and congenital defects in humans has been demonstrated.

5.3 Evaluation

The available experimental and human data are insufficient to evaluate the carcinogenicity of clomiphene citrate.

Subsequent evaluation: Suppl. 7 (1987)


Last updated 01/12/98






















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