International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 21 (1979) (p. 161)
5. Summary of Data Reported and Evaluation
(N.B. - This section should be read in conjunction with the General Remarks on Sex Hormones and with
the General Conclusions on Sex Hormones.)
5.1 Experimental data
Dienoestrol was tested in female guinea-pigs by subcutaneous injection
and in female mice by intravaginal administration. Although pointing
to the induction of 'uterine tumours' in guinea-pigs and ovarian
tumours in mice, these experiments were insufficient to evaluate the
carcinogenicity of this compound.
5.2 Human data
No case reports or epidemiological studies on dienoestrol alone were
available to the Working Group. Case reports and epidemiological studies
on steroid hormones used in oestrogen treatment have been summarized in the section,
'Oestrogens and Progestins in Relation to Human Cancer'.
The available experimental data are insufficient to evaluate the
carcinogenicity of dienoestrol in animals. Studies in humans strongly
suggest that the administration of oestrogens is causally related to
an increased incidence of endometrial carcinoma; there is no evidence
that dienoestrol is different from other oestrogens in this respect.
Subsequent evaluation: Suppl. 7 (1987) (Nonsteroidal oestrogens)
Last updated: 6 April 1998