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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

PROFLAVINE, PROFLAVINE DIHYDROCHLORIDE,
PROFLAVINE HEMISULPHATE AND
PROFLAVINE MONOHYDROCHLORIDE

VOL.: 24 (1980) (p. 195)

Proflavin
CAS No.: 92-62-6
Chem. Abstr. Name: 3,6-Acridinediamine

Proflavine dihydrochloride
CAS No.: 531-73-7
Chem. Abstr. Name: 3,6-Acridinediamine, dihydrochloride

Proflavine hemisulphate
CAS No.: 1811-28-5
Chem. Abstr. Name: 3,6-Acridinediamine, sulfate (2:1)

Proflavine monohydrochloride
CAS No.: 952-23-8
Chem. Abstr. Name: 3,6-Acridinediamine monohydrochloride

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Proflavine monohydrochloride, as the hemihydrate, was tested in mice and rats by oral administration. Proflavine hemisulphate was tested in mice by skin application, intradermal administration and subcutaneous implantation. All tests were inadequate for evaluation.

Proflavine is mutagenic in viral and bacterial systems. It increased the number of chromatid breaks and induced sister chromatid exchanges in mammalian cells.

Attention is drawn to the absence of studies on the teratogenicity of this compound.

5.2 Human data

Proflavine and its salts have limited use as topical disinfectants.

No case reports or epidemiological studies were available to the Working Group.

5.3 Evaluation

The available experimental results were inadequate for an evaluation of the carcinogenicity of proflavine in experimental animals, and no data were available from human studies. However, in view of its mutagenicity, confirmed in several experimental systems, further studies on the carcinogenicity of this compound are warranted.

Subsequent evaluation: Suppl. 7 (1987) (p. 70: Proflavine salts - Group 3)

For definition of italicized terms, see Preamble Evaluation.

Synonyms for Proflavin

Synonyms for Proflavine dihydrochloride

Synonyms for Proflavine hemisulphate

Synonyms for Proflavine monohydrochloride


Last updated: 7 April 1998






















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       Toxicological Abbreviations