International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 24 (1980) (p. 285)
5. Summary of Data Reported and Evaluation
5.1 Experimental data
Sulfamethoxazole was tested in one experiment in rats by oral
administration: it produced thyroid tumours.
No mutagenic effects were observed. Attention is drawn to the absence
of studies on the teratogenicity of this compound.
5.2 Human data
Sulfamethoxazole is commonly used in the treatment of urinary-tract
In one hypothesis-seeking epidemiological study, an association
between sulfamethoxazole use and nasopharyngeal and cervical cancers
There is limited evidence for the carcinogenicity of
sulfamethoxazole in experimental animals. The epidemiological data
were insufficient. No evaluation of the carcinogenicity of
sulfamethoxazole to humans could be made.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987);
Vol. 79 (2001)
Last updated: 7 April 1998