VOL.: 26 (1981) (p. 151)
In mice, high doses of cisplatin can induce embryolethality. The limited data available do not allow an evaluation of the teratogenic potential of the drug.
Cisplatin is a mutagen in bacterial and cultured mammalian cells. It also induces chromosomal aberrations in various cells in culture and in mice in vivo. Additionally, treatment of Syrian hamster embryo cells in culture with the drug resulted in the induction of morphological transformation.
No data were available to evaluate the teratogenic potential or the mutagenicity or chromosomal effects of cisplatin in humans.
No case report or epidemiological study was available to the Working Group.
The available data were insufficient for the Working Group to evaluate the carcinogenicity of cisplatin to humans.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987)
See Also: Toxicological Abbreviations Cisplatin (PIM 132) Cisplatin (UKPID)