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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

1,5-NAPHTHALENEDIAMINE

VOL.: 27 (1982) (p. 127)

CAS No.: 2243-62-1
Chem. Abstr. Name: 1,5-Naphthalenediamine

5. Summary of Data Reported and Evaluation

5.1 Experimental data

1,5-Naphthalenediamine (technical grade) was tested in one experiment in mice and in one experiment in rats by dietary administration. It produced adenomas of the thyroid in male mice and carcinomas and adenomas of the thyroid and lungs and carcinomas of the liver in female mice. The experiment in rats was inadequate for evaluation.

1,5-Naphthalenediamine (technical-grade) was mutagenic to Salmonella typhimurium.

5.2 Human data

1,5-Naphthalenediamine has been produced commercially since at least 1957. Its use as an intermediate in the manufacture of 1,5-naphthalene diisocyanate and of dyes could result in occupational exposure.

No case report or epidemiological study was available to the Working Group.

5.3 Evaluation

There is limited evidence for the carcinogenicity of 1,5-naphthalenediamine in experimental animals.

No evaluation of the carcinogenicity of 1,5-naphthalenediamine to humans could be made.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 67: Group 3)

Synonyms


Last updated: 8 April 1998






















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