International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 27 (1982) (p. 199)
CAS No.: 82-28-0
Chem. Abstr. Name: 9,10-Anthracenedione, 1-amino-2-methyl-
5. Summary of Data Reported and Evaluation
5.1 Experimental data
1-Amino-2-methylanthraquinone (technical grade, maximum purity 68%)
was tested in one experiment in mice and one experiment in rats by
dietary administration. This material increased the incidence of
hepatocellular carcinomas in rats of both sexes and of kidney adenomas
and adenocarcinomas in males. The experiment in mice was inadequate
No data on the mutagenicity of this compound were available.
5.2 Human data
1-Amino-2-methylanthraquinone was first produced commercially in 1948.
It has been used as a dye intermediate in the US and is still produced
in commercial quantities in western Europe. Its continued production
could lead to occupational exposure.
No case report or epidemiological study was available to the Working
There is limited evidence for the carcinogenicity in experimental
animals of the material tested, which was technical-grade
1-amino-2-methylanthraquinone of low purity.
In view of the uncertain purity of the compound tested and in the
absence of data on humans, no evaluation of the carcinogenicity of
1-amino-2-methylanthraquinone could be made.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 57: Group 3)
- Acetate Fast Orange R
- Acetoquinone Light Orange JL
- Artisil Orange 3RP
- Celliton Orange R
- C.I. Disperse Orange 11
- C.I. 60700
- Cilla Orange R
- Disperse Orange
- Disperse Orange (anthraquinone dye)
- Duranol Orange G
- Microsetile Orange RA
- Nyloquinone Orange JR
- Perliton Orange 3R
- Serisol Orange YL
- Supracet Orange R
Last updated: 8 April 1998