International Agency for Research on Cancer (IARC) - Summaries & Evaluations
5-NITRO-ortho-ANISIDINE
VOL.: 27 (1982) (p. 133)
CAS No.: 99-59-2
Chem. Abstr. Name: Benzenamine, 2-methoxy-5-nitro-
5. Summary of Data Reported and Evaluation
5.1 Experimental data
5-Nitro-ortho-anisidine was tested for carcinogenicity in one
experiment in mice and in one experiment in rats by dietary
administration. It produced skin carcinomas in male rats, carcinomas
of the Zymbal gland or skin of the ear in male and female rats,
mammary adenocarcinomas in female rats and adenomas or carcinomas of
the preputial and clitoral glands in male and female rats,
respectively. The experiment in mice was inadequate for evaluation.
5-Nitro-ortho-anisidine was mutagenic to Salmonella typhimurium.
5.2 Human data
5-Nitro-ortho-anisidine has been produced commercially since at least
1937. Its principal use as a dye intermediate could result in
occupational exposure.
No case report or epidemiological study was available to the Working
Group.
5.3 Evaluation
There is limited evidence for the carcinogenicity of
5-nitro-ortho-anisidine in experimental animals.
No evaluation of the carcinogenicity of 5-nitro-ortho-anisidine to
humans could be made.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 67: Group 3)
Synonyms
- 2-Amino-1-methoxy-4-nitrobenzene
- 2-Amino-4-nitroanisole
- ortho-Anisidine nitrate
- Azoamine Scarlet K
- Azogene Ecarlate R
- Azoic Diazo Component 13, Base
- 2-Methoxy-5-nitroaniline
- 3-Nitro-6-methoxyaniline
- 5-Nitro-2-methoxyaniline
Last updated: 8 April 1998