IPCS INCHEM Home

International Agency for Research on Cancer (IARC) - Summaries & Evaluations

2,4,5- AND 2,4,6-TRIMETHYLANILINE
AND THEIR HYDROCHLORIDES

VOL.: 27 (1982) (p. 177)

2,4,5-Trimethylaniline
CAS No.: 137-17-7
Chem. Abstr. Name: Benzenamine, 2,4,5-trimethyl-

2,4,5-Trimethylaniline hydrochloride
CAS No.: 21436-97-5
Chem. Abstr. Name: Benzenamine, 2,4,5-trimethyl-, hydrochloride

2,4,6-Trimethylaniline
CAS No.: 88-05-1
Chem. Abstr. Name: Benzenamine, 2,4,6-trimethyl-

2,4,6-Trimethylaniline hydrochloride
CAS No.: 6334-11-8
Chem. Abstr. Name: Benzenamine, 2,4,6-trimethyl-, hydrochloride

5. Summary of Data Reported and Evaluation

5.1 Experimental data

2,4,5-Trimethylaniline and its hydrochloride were tested in two experiments in mice and in two experiments in rats by dietary administration. In one experiment in mice, 2,4,5-trimethylaniline produced an increased incidence of hepatocellular carcinomas in female mice. The other experiment in mice was considered inadequate for an evaluation. In one experiment in rats it produced an increased incidence of liver carcinomas and lung adenomas. In the other experiment in rats no significantly increased incidence of tumours was observed.

2,4,6-Trimethylaniline hydrochloride was tested in one experiment in mice and in one experiment in male rats. These experiments were considered inadequate for evaluation.

2,4,5-Trimethylaniline was mutagenic to Salmonella typhimurium with metabolic activation. The available data were inadequate to evaluate the mutagenicity of 2,4,6-trimethylaniline.

5.2 Human data

2,4,5-Trimethylaniline has been produced commercially in the past. 2,4,6-Trimethylaniline is believed to be produced in commercial quantities, but its uses and the extent of human exposure are unknown. The hydrochloride salts of these two compounds are not produced commercially.

No case report or epidemiological study was available to the Working Group.

5.3 Evaluation

There is limited evidence for the carcinogenicity of 2,4,5-trimethylaniline in experimental animals. No evaluation of the carcinogenicity of 2,4,5-trimethylaniline to humans could be made.

The available data were inadequate for an evaluation of the carcinogenicity of 2,4,6-trimethylaniline in experimental animals to be made. No evaluation of the carcinogenicity of 2,4,6-trimethylaniline to humans could be made.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 73: Group 3)

Synonyms for 2,4,5-Trimethylaniline

Synonyms for 2,4,5-Trimethylaniline hydrochloride

Synonyms for 2,4,6-Trimethylaniline

Synonyms for 2,4,6-Trimethylaniline hydrochloride


Last updated: 8 April 1998






















    See Also:
       Toxicological Abbreviations