VOL.: 29 (1982) (p. 239)
3,3'-Dichlorobenzidine is mutagenic to Salmonella typhimurium with or without metabolic activation and induces unscheduled DNA synthesis in HeLa cells.
No data were available on the teratogenicity of this compound to experimental animals.
No data were available to assess the mutagenicity or teratogenicity of this compound to man.
No case report on exposure to 3,3'-dichlorobenzidine was available to the Working Group. Although three retrospective epidemiological studies of workers exposed to 3,3'-dichlorobenzidine gave no evidence for carcinogenicity, the studies were of insufficient quality or statistical power to permit confident exclusion of that possibility. Because 3,3'-dichlorobenzidine and benzidine may be made in the same plant, the possibility cannot be excluded that dichlorobenzidine has contributed to the incidence of human bladder cancer attributed to benzidine.
The epidemiological data are inadequate to evaluate the carcinogenicity of 3,3'-dichlorobenzidine to man.
For definition of the italicized terms, see Preamble Evaluation.
Previous evaluation: Vol. 4 (1974)
Subsequent evaluation: Suppl. 7 (1987)
See Also: Toxicological Abbreviations Dichlorobenzidine, 3,3'- (IARC Summary & Evaluation, Supplement7, 1987)