International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 29 (1982) (p. 203)
CAS No.: 101-80-4
Chem. Abstr. Name: Benzenamine, 4,4'-oxybis-
5. Summary of Data Reported and Evaluation
5.1 Experimental data
4,4'-Diaminodiphenyl ether was tested in mice and rats by oral
administration and by subcutaneous injection. In two studies in rats,
it produced benign and malignant liver-cell tumours following oral or
subcutaneous administration; and following its oral administration in
one study, benign and malignant follicular-cell tumours of the thyroid
were produced. Other studies in rats by oral and subcutaneous
administration were not adequate for evaluation. In a study in mice
by oral administration it produced benign and malignant liver-cell
tumours in females given the high dose and in males given the low
dose and adenomas of the Harderian gland in animals of both sexes.
4,4'-Diaminodiphenyl ether is mutagenic to Salmonella typhimurium
with metabolic activation.
No data were available to assess its teratogenicity to experimental
5.2 Human data
Occupational exposure to 4,4'-diaminodiphenyl ether probably occurs
during its manufacture and its conversion to polyimide-type resins.
No data were available to assess the mutagenicity or teratogenicity of
this compound to man.
No case report or epidemiological study was available to the Working
There is sufficient evidence for the carcinogenicity of
4,4'-diaminodiphenyl ether in mice and rats.
No case report or epidemiological study was available.
For definition of the italicized terms, see Preamble Evaluation.
Previous evaluation: Vol. 16 (1978)
Subsequent evaluation: Suppl. 7 (1987) (p. 61: Group 2B)
- 4-Aminophenyl ether
- para-Aminophenyl ether
- Bis(4-aminophenyl) ether
- 4,4'-Diaminobiphenyl ether
- Diaminodiphenyl ether
- para,para'-Diaminodiphenyl ether
- 4,4'-Diaminodiphenyl oxide
- 4,4'-Diaminophenyl ether
- 4,4'-Diaminophenyl oxide
Last updated: 9 April 1998