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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

BENZOYL CHLORIDE

VOL.: 29 (1982) (p. 83)

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Benzoyl chloride was tested in two sets of experiments by skin application to female mice. A few skin carcinomas were observed in treated mice, but their incidence was not statistically significant.

There is no clear evidence that benzoyl chloride is mutagenic in bacterial systems; it was negative in a rec-assay with Bacillus subtilis.

No data were available to assess the teratogenicity of this compound to experimental animals.

5.2 Human data

Occupational exposure to benzoyl chloride has and probably still does occur during its manufacture and use in the production of benzoyl peroxide, herbicides and other derivatives.

No data were available to assess the mutagenicity or teratogenicity of this compound to man.

No case report or epidemiological study involving exposure to benzoyl chloride alone was available to the Working Group. Six cases of respiratory cancer have been reported among benzoyl chloride production workers in two small plants. The cases occurred in young workers, three of whom were nonsmokers.

5.3 Evaluation

There was inadequate evidence for the carcinogenicity of benzoyl chloride in experimental animals.

Although the epidemiological data were inadequate to evaluate the carcinogenicity of benzoyl chloride alone, they provide limited evidence that employment in the production of benzoyl chloride and its chlorinated toluene derivatives represents a carcinogenic risk to man.

No evaluation could be made on the carcinogenicity to man of benzoyl chloride itself.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987); Vol. 71 (1999)


Last updated: 9 April 1998






















    See Also:
       Toxicological Abbreviations
       Benzoyl chloride (ICSC)