International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 30 (1983) (p. 235)
CAS No.: 2303-16-4
Chem. Abstr. Name: Carbamothioic acid, bis(1-methylethyl)-, S-(2,3-dichloro-2-
5. Summary of Data Reported and Evaluation
5.1 Experimental data
Diallate was tested for carcinogenicity in two strains of mice by
oral and subcutaneous administration and in one strain of rats by oral
administration. Following its administration in the diet, the
incidence of hepatomas was increased in male mice of both strains, and
the incidence of lung adenomas was increased in male mice of one
strain. The study in rats was considered to be inadequate for
No data were available to evaluate the teratogenicity of diallate
to experimental animals.
Diallate was mutagenic in bacteria and yeasts. It induced
mutations in Drosophila melanogaster, and unscheduled DNA synthesis,
sister chromatid exchange, gene mutations and chromosomal aberrations
in cultured mammalian cells. Exogenous metabolic activation was
usually required to produce or enhance mutagenic activity. Diallate
was ineffective in a dominant lethal test in mice. There is
sufficient evidence that diallate is mutagenic in cellular systems,
but insufficient evidence for its mutagenicity in mammals.
5.2 Human data
Diallate was introduced in 1960. Its production, formulation and
use as a herbicide in agricultural applications are potential sources
of exposure, both of workers and of the general population.
No data were available to evaluate the teratogenic or chromosomal
effects of diallate in humans.
No case report or epidemiological study of the carcinogenicity of
diallate alone was available to the Working Group. (See, however, the
section 'Cancer Epidemiology of Pesticide Manufacturers, Formulators
and Users', in this volume.)
Results of experiments in mice provide limited evidence that
diallate is carcinogenic to experimental animals. No data on humans
The available data are insufficient to evaluate the
carcinogenicity of diallate to humans.
For definition of the italicized terms, see Preamble Evaluation.
Previous evaluation: Vol. 12 (1976)
Subsequent evaluation: Suppl. 7 (1987) (p. 61: Group 3)
- Bis(1-methylethyl)carbamothioic acid S-(2,3-dichloro-2-propenyl) ester
- CP 15336
- Dichloroallyl diisopropylthiocarbamate
- 2,3-Dichloroallyl N,N-diisopropylthiocarbamate
- 2,3-Dichloro-2-propene-1-thiol diisopropylcarbamate
- Diisopropylthiocarbamic acid S-(2,3-dichloroallyl) ester
Last updated: 16 April 1998