VOL.: 30 (1983) (p. 87)
Chem. Abstr. Name: Benzenemethanol, 4-chloro-a-(4-chlorophenyl)-a-(trichloromethyl)-
Dicofol (technical-grade), even when given at high doses, had no effect on reproduction or foetal development in mice; however, high doses in rats appeared to have an adverse effect on preimplantation stages of embryonal development.
Dicofol was negative in bacterial tests for mutagenicity and for DNA damage, with or without exogenous metabolic activation. The experimental protocols and results of studies with eukaryotes were not presented in adequate detail for an evaluation to be made. No overall evaluation of the mutagenicity of dicofol could be made.
No data were available to evaluate the teratogenic or chromosomal effects of dicofol in humans.
No case report or epidemiological study of the carcinogenicity of dicofol alone was available to the Working Group. (See, however, the section 'Cancer Epidemiology of Pesticide Manufacturers, Formulators and Users', in this volume.)
The available data are insufficient to evaluate the carcinogenicity of dicofol to humans.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 62: Group 3)
See Also: Toxicological Abbreviations Dicofol (ICSC) Dicofol (PDS) Dicofol (FAO/PL:1968/M/9/1) Dicofol (AGP:1970/M/12/1) Dicofol (WHO Pesticide Residues Series 4) Dicofol (Pesticide residues in food: 1992 evaluations Part II Toxicology)