VOL.: 30 (1983) (p. 183)
Chem. Abstr. Name: 1,3-Benzodioxole, 5[(2-[2-butoxyethoxy]ethoxy)methyl]-6-propyl
Treatment of rats with high doses of piperonyl butoxide during organogenesis did not affect foetal development; however, its continued administration at high dose levels for three generations caused reduction in the number of pregnancies and offspring.
Piperonyl butoxide has been reported to be nonmutagenic to bacteria, silkworms and cultured mammalian cells. A dominant lethal study in mice was inconclusive. Lack of availability to the Group of much of the detailed data prevented overall evaluation of the mutagenicity of piperonyl butoxide, but all cited results have been negative.
The available data were insufficient to evaluate the teratogenicity of piperonyl butoxide to humans. No data were available to evaluate its chromosomal effects in humans.
No case report or epidemiological study of the carcinogenicity of piperonyl butoxide alone was available to the Working Group. (See also the section 'Cancer Epidemiology of Pesticide Manufacturers, Formulators and Users', in this volume.)
The available data provide no evidence that piperonyl butoxide is likely to present a carcinogenic risk to humans.
Subsequent evaluation: Suppl. 7 (1987) (p. 70: Group 3)
See Also: Toxicological Abbreviations Piperonyl butoxide (ICSC) Piperonyl Butoxide (FAO Meeting Report PL/1965/10/1) Piperonyl butoxide (FAO/PL:CP/15) Piperonyl butoxide (FAO/PL:1967/M/11/1) Piperonyl Butoxide (FAO/PL:1969/M/17/1) Piperonyl butoxide (WHO Pesticide Residues Series 2) Piperonyl butoxide (Pesticide residues in food: 1992 evaluations Part II Toxicology) Piperonyl butoxide (Pesticide residues in food: 1995 evaluations Part II Toxicological & Environmental)