International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 30 (1983) (p. 207)
CAS No.: 52-68-6
Chem. Abstr. Name: Phosphoric acid, (2,2,2-trichloro-1-hydroxyethyl)-, dimethyl ester
5. Summary of Data Reported and Evaluation
5.1 Experimental data
Trichlorfon was tested for carcinogenicity by oral administration
in mice and rats, by intraperitoneal administration in mice, rats and
hamsters, by dermal application in mice and by intramuscular
administration in rats. The studies in mice and two of the studies in
rats were considered inadequate for evaluation. The other studies in
rats and that in hamsters were not indicative of a carcinogenic
Trichlorfon was teratogenic to mice, rats and hamsters when given
at dose levels which also caused reductions in maternal food intake
and maternal body weight gain.
There is sufficient evidence that trichlorfon or its degradation
products is mutagenic in bacteria, mammalian cells and mice.
Inconsistent results have been reported with many systems, however,
and the instability of trichlorfon may be an important consideration
in interpreting these data.
5.2 Human data
Trichlorfon was introduced in 1952. Its use as an insecticide in
agricultural applications is a potential source of exposure, both of
workers and of the general population. Its use in human medicine as
an anthelmintic is another possible source of human exposure.
No data were available to evaluate the teratogenic effects of
trichlorfon in humans. The available data were insufficient to
evaluate the chromosomal effects of trichlorfon in humans.
No case report or epidemiological study of the carcinogenicity of
trichlorfon alone was available to the Working Group. (See, however,
the section 'Cancer Epidemiology of Pesticide Manufacturers, Users and
Formulators', in this volume.)
The available data, while providing no evidence that trichlorfon
is carcinogenic to mice or rats, were considered inadequate to
evaluate the carcinogenicity of this compound to experimental animals.
In view of its mutagenicity, confirmed in several experimental
systems, further studies on the carcinogenicity of this compound are
warranted. The Working Group was aware that a long-term bioassay was
No data on humans were available.
The available data are insufficient to evaluate the
carcinogenicity of trichlorfon to humans.
Subsequent evaluation: Suppl. 7 (1987) (p. 73: Group 3)
- Aerol 1
- Bay 15922
- Bayer 15922
- Bayer L l3/59
- Dimethoxy-2,2,2-trichloro-1-hydroxyethyl phosphine oxide
- Dimethyl ester of 2,2,2-trichloro-1-hydroxyethyl phosphonate
- Dimethyl 1-hydroxy-2,2,2-trichloroethylphosphonate
- Dimethyltrichlorohydroxyethyl phosphonate
- ENT 19,763
- Flibol E
- Foschlor R & R50
- 1-Hydroxyethyl) dimethylphosphonate
- 1-Hydroxy-2,2,2-trichloroethylphosphonic acid dimethyl ester
- Methyl chlorophos
- Neguvon A
- Phoschlor R50
- Satox 20WSC
- (2,2,2-Trichloro-1-hydroxyethyl) phosphonic acid dimethyl ester
- Tugon Stable Spray
- Tugon Fly Bait
- Vermicide Bayer 2349
- WEC 50
Last updated: 16 April 1998